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Growth to early adulthood following extremely preterm birth: the EPICure study.


ABSTRACT:

Objective

To investigate growth trajectories from age 2.5 to 19 years in individuals born before 26 weeks of gestation (extremely preterm; EP) compared with term-born controls.

Methods

Multilevel modelling of growth data from the EPICure study, a prospective 1995 birth cohort of 315 EP participants born in the UK and Ireland and 160 term-born controls recruited at school age. Height, weight, head circumference and body mass index (BMI) z-scores were derived from UK standards at ages 2.5, 6, 11 and 19 years.

Results

129 (42%) EP children were assessed at 19 years. EP individuals were on average 4.0?cm shorter and 6.8?kg lighter with a 1.5?cm smaller head circumference relative to controls at 19 years. Relative to controls, EP participants grew faster in weight by 0.06 SD per year (95%?CI 0.05 to 0.07), in head circumference by 0.04 SD (95% CI 0.03 to 0.05), but with no catch-up in height. For the EP group, because of weight catch-up between 6 and 19 years, BMI was significantly elevated at 19 years to +0.32?SD; 23.4% had BMI >25?kg/m2 and 6.3% >30?kg/m2 but these proportions were similar to those in control subjects. EP and control participants showed similar pubertal development in early adolescence, which was not associated with height at 19 years in either study group. Growth through childhood was related to birth characteristics and to neonatal feeding practices.

Conclusions

EP participants remained shorter and lighter and had smaller head circumferences than reference data or controls in adulthood but had elevated BMI.

SUBMITTER: Ni Y 

PROVIDER: S-EPMC7115967 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Publications

Growth to early adulthood following extremely preterm birth: the EPICure study.

Ni Yanyan Y   Beckmann Joanne J   Gandhi Rashmi R   Hurst John R JR   Morris Joan K JK   Marlow Neil N  

Archives of disease in childhood. Fetal and neonatal edition 20200106 5


<h4>Objective</h4>To investigate growth trajectories from age 2.5 to 19 years in individuals born before 26 weeks of gestation (extremely preterm; EP) compared with term-born controls.<h4>Methods</h4>Multilevel modelling of growth data from the EPICure study, a prospective 1995 birth cohort of 315 EP participants born in the UK and Ireland and 160 term-born controls recruited at school age. Height, weight, head circumference and body mass index (BMI) z-scores were derived from UK standards at ag  ...[more]

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