Male-specific alterations in structure of isolation call sequences of mouse pups with 16p11.2 deletion.

ABSTRACT: 16p11.2 deletion is one of the most common gene copy variations that increases the susceptibility to autism and other neurodevelopmental disorders. This syndrome leads to developmental delays, including speech impairment and delays in expressive language and communication skills. To study developmental impairment of vocal communication associated with 16p11.2 deletion syndrome, we used the 16p11.2del mouse model and performed an analysis of pup isolation calls (PICs). The earliest PICs at postnatal day 5 from 16p11.2del pups were found altered in a male-specific fashion relative to wild-type (WT) pups. Analysis of sequences of ultrasonic vocalizations (USVs) emitted by pups using mutual information between syllables at different positions in the USV spectrograms showed that dependencies ex

SUBMITTER: Agarwalla S 

PROVIDER: S-EPMC7116069 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature