Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
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ABSTRACT:
SUBMITTER: Erzurumluoglu AM
PROVIDER: S-EPMC7116129 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
Erzurumluoglu A Mesut AM Liu Mengzhen M Jackson Victoria E VE Barnes Daniel R DR Datta Gargi G Melbourne Carl A CA Young Robin R Batini Chiara C Surendran Praveen P Jiang Tao T Adnan Sheikh Daud SD Afaq Saima S Agrawal Arpana A Altmaier Elisabeth E Antoniou Antonis C AC Asselbergs Folkert W FW Baumbach Clemens C Bierut Laura L Bertelsen Sarah S Boehnke Michael M Bots Michiel L ML Brazel David M DM Chambers John C JC Chang-Claude Jenny J Chen Chu C Corley Janie J Chou Yi-Ling YL David Sean P SP de Boer Rudolf A RA de Leeuw Christiaan A CA Dennis Joe G JG Dominiczak Anna F AF Dunning Alison M AM Easton Douglas F DF Eaton Charles C Elliott Paul P Evangelou Evangelos E Faul Jessica D JD Foroud Tatiana T Goate Alison A Gong Jian J Grabe Hans J HJ Haessler Jeff J Haiman Christopher C Hallmans Göran G Hammerschlag Anke R AR Harris Sarah E SE Hattersley Andrew A Heath Andrew A Hsu Chris C Iacono William G WG Kanoni Stavroula S Kapoor Manav M Kaprio Jaakko J Kardia Sharon L SL Karpe Fredrik F Kontto Jukka J Kooner Jaspal S JS Kooperberg Charles C Kuulasmaa Kari K Laakso Markku M Lai Dongbing D Langenberg Claudia C Le Nhung N Lettre Guillaume G Loukola Anu A Luan Jian'an J Madden Pamela A F PAF Mangino Massimo M Marioni Riccardo E RE Marouli Eirini E Marten Jonathan J Martin Nicholas G NG McGue Matt M Michailidou Kyriaki K Mihailov Evelin E Moayyeri Alireza A Moitry Marie M Müller-Nurasyid Martina M Naheed Aliya A Nauck Matthias M Neville Matthew J MJ Nielsen Sune Fallgaard SF North Kari K Perola Markus M Pharoah Paul D P PDP Pistis Giorgio G Polderman Tinca J TJ Posthuma Danielle D Poulter Neil N Qaiser Beenish B Rasheed Asif A Reiner Alex A Renström Frida F Rice John J Rohde Rebecca R Rolandsson Olov O Samani Nilesh J NJ Samuel Maria M Schlessinger David D Scholte Steven H SH Scott Robert A RA Sever Peter P Shao Yaming Y Shrine Nick N Smith Jennifer A JA Starr John M JM Stirrups Kathleen K Stram Danielle D Stringham Heather M HM Tachmazidou Ioanna I Tardif Jean-Claude JC Thompson Deborah J DJ Tindle Hilary A HA Tragante Vinicius V Trompet Stella S Turcot Valerie V Tyrrell Jessica J Vaartjes Ilonca I van der Leij Andries R AR van der Meer Peter P Varga Tibor V TV Verweij Niek N Völzke Henry H Wareham Nicholas J NJ Warren Helen R HR Weir David R DR Weiss Stefan S Wetherill Leah L Yaghootkar Hanieh H Yavas Ersin E Jiang Yu Y Chen Fang F Zhan Xiaowei X Zhang Weihua W Zhao Wei W Zhao Wei W Zhou Kaixin K Amouyel Philippe P Blankenberg Stefan S Caulfield Mark J MJ Chowdhury Rajiv R Cucca Francesco F Deary Ian J IJ Deloukas Panos P Di Angelantonio Emanuele E Ferrario Marco M Ferrières Jean J Franks Paul W PW Frayling Tim M TM Frossard Philippe P Hall Ian P IP Hayward Caroline C Jansson Jan-Håkan JH Jukema J Wouter JW Kee Frank F Männistö Satu S Metspalu Andres A Munroe Patricia B PB Nordestgaard Børge Grønne BG Palmer Colin N A CNA Salomaa Veikko V Sattar Naveed N Spector Timothy T Strachan David Peter DP van der Harst Pim P Zeggini Eleftheria E Saleheen Danish D Butterworth Adam S AS Wain Louise V LV Abecasis Goncalo R GR Danesh John J Tobin Martin D MD Vrieze Scott S Liu Dajiang J DJ Howson Joanna M M JMM
Molecular psychiatry 20190107 10
Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). I ...[more]