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Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

ABSTRACT: Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). In a subset of 112,811 participants, a further one million SNVs were also genotyped and tested for association with the four smoking behaviour traits. SNV-trait associations with P?

SUBMITTER: Erzurumluoglu AM 

PROVIDER: S-EPMC7116129 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

Erzurumluoglu A Mesut AM   Liu Mengzhen M   Jackson Victoria E VE   Barnes Daniel R DR   Datta Gargi G   Melbourne Carl A CA   Young Robin R   Batini Chiara C   Surendran Praveen P   Jiang Tao T   Adnan Sheikh Daud SD   Afaq Saima S   Agrawal Arpana A   Altmaier Elisabeth E   Antoniou Antonis C AC   Asselbergs Folkert W FW   Baumbach Clemens C   Bierut Laura L   Bertelsen Sarah S   Boehnke Michael M   Bots Michiel L ML   Brazel David M DM   Chambers John C JC   Chang-Claude Jenny J   Chen Chu C   Corley Janie J   Chou Yi-Ling YL   David Sean P SP   de Boer Rudolf A RA   de Leeuw Christiaan A CA   Dennis Joe G JG   Dominiczak Anna F AF   Dunning Alison M AM   Easton Douglas F DF   Eaton Charles C   Elliott Paul P   Evangelou Evangelos E   Faul Jessica D JD   Foroud Tatiana T   Goate Alison A   Gong Jian J   Grabe Hans J HJ   Haessler Jeff J   Haiman Christopher C   Hallmans Göran G   Hammerschlag Anke R AR   Harris Sarah E SE   Hattersley Andrew A   Heath Andrew A   Hsu Chris C   Iacono William G WG   Kanoni Stavroula S   Kapoor Manav M   Kaprio Jaakko J   Kardia Sharon L SL   Karpe Fredrik F   Kontto Jukka J   Kooner Jaspal S JS   Kooperberg Charles C   Kuulasmaa Kari K   Laakso Markku M   Lai Dongbing D   Langenberg Claudia C   Le Nhung N   Lettre Guillaume G   Loukola Anu A   Luan Jian'an J   Madden Pamela A F PAF   Mangino Massimo M   Marioni Riccardo E RE   Marouli Eirini E   Marten Jonathan J   Martin Nicholas G NG   McGue Matt M   Michailidou Kyriaki K   Mihailov Evelin E   Moayyeri Alireza A   Moitry Marie M   Müller-Nurasyid Martina M   Naheed Aliya A   Nauck Matthias M   Neville Matthew J MJ   Nielsen Sune Fallgaard SF   North Kari K   Perola Markus M   Pharoah Paul D P PDP   Pistis Giorgio G   Polderman Tinca J TJ   Posthuma Danielle D   Poulter Neil N   Qaiser Beenish B   Rasheed Asif A   Reiner Alex A   Renström Frida F   Rice John J   Rohde Rebecca R   Rolandsson Olov O   Samani Nilesh J NJ   Samuel Maria M   Schlessinger David D   Scholte Steven H SH   Scott Robert A RA   Sever Peter P   Shao Yaming Y   Shrine Nick N   Smith Jennifer A JA   Starr John M JM   Stirrups Kathleen K   Stram Danielle D   Stringham Heather M HM   Tachmazidou Ioanna I   Tardif Jean-Claude JC   Thompson Deborah J DJ   Tindle Hilary A HA   Tragante Vinicius V   Trompet Stella S   Turcot Valerie V   Tyrrell Jessica J   Vaartjes Ilonca I   van der Leij Andries R AR   van der Meer Peter P   Varga Tibor V TV   Verweij Niek N   Völzke Henry H   Wareham Nicholas J NJ   Warren Helen R HR   Weir David R DR   Weiss Stefan S   Wetherill Leah L   Yaghootkar Hanieh H   Yavas Ersin E   Jiang Yu Y   Chen Fang F   Zhan Xiaowei X   Zhang Weihua W   Zhao Wei W   Zhao Wei W   Zhou Kaixin K   Amouyel Philippe P   Blankenberg Stefan S   Caulfield Mark J MJ   Chowdhury Rajiv R   Cucca Francesco F   Deary Ian J IJ   Deloukas Panos P   Di Angelantonio Emanuele E   Ferrario Marco M   Ferrières Jean J   Franks Paul W PW   Frayling Tim M TM   Frossard Philippe P   Hall Ian P IP   Hayward Caroline C   Jansson Jan-Håkan JH   Jukema J Wouter JW   Kee Frank F   Männistö Satu S   Metspalu Andres A   Munroe Patricia B PB   Nordestgaard Børge Grønne BG   Palmer Colin N A CNA   Salomaa Veikko V   Sattar Naveed N   Spector Timothy T   Strachan David Peter DP   van der Harst Pim P   Zeggini Eleftheria E   Saleheen Danish D   Butterworth Adam S AS   Wain Louise V LV   Abecasis Goncalo R GR   Danesh John J   Tobin Martin D MD   Vrieze Scott S   Liu Dajiang J DJ   Howson Joanna M M JMM  

Molecular psychiatry 20190107 10

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). I  ...[more]