Microarray-Based Detection of Allergen-Reactive IgE in Patients with Mastocytosis.

ABSTRACT:

Background

Because of a high risk to develop fatal anaphylaxis, early detection of immunoglobulin E (IgE)-dependent allergy is of particular importance in patients with mastocytosis.

Objective

We examined whether microarray-based screening for allergen-reactive IgE (allergen-chip) is a sensitive and robust approach to detect specific IgE in patients with mastocytosis.

Methods

Sera for 42 patients were analyzed, including 4 with cutaneous mastocytosis, 2 with mastocytosis in the skin, and 36 with systemic mastocytosis. In addition, sera from an age- and sex-matched control cohort (n = 42) were analyzed.

Results

In 15 of 42 patients with mastocytosis (35.7%), specific IgE was detected by allergen-chip profiling. Ves v 5 and Bet v 1 were the most frequently detect

SUBMITTER: Smiljkovic D 

PROVIDER: S-EPMC7116130 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature