Model-Based Detection of Whole-Genome Duplications in a Phylogeny.

ABSTRACT: Ancient whole-genome duplications (WGDs) leave signatures in comparative genomic data sets that can be harnessed to detect these events of presumed evolutionary importance. Current statistical approaches for the detection of ancient WGDs in a phylogenetic context have two main drawbacks. The first is that unwarranted restrictive assumptions on the "background" gene duplication and loss rates make inferences unreliable in the face of model violations. The second is that most methods can only be used to examine a limited set of a priori selected WGD hypotheses and cannot be used to discover WGDs in a phylogeny. In this study, we develop an approach for WGD inference using gene count data that seeks to overcome both issues. We employ a phylogenetic birth-death model that includes WGD in a fle

SUBMITTER: Zwaenepoel A 

PROVIDER: S-EPMC7116244 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature