Ontology highlight
ABSTRACT:
SUBMITTER: Schuijs MJ
PROVIDER: S-EPMC7116357 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Schuijs Martijn J MJ Png Shaun S Richard Arianne C AC Tsyben Anastasia A Hamm Gregory G Stockis Julie J Garcia Celine C Pinaud Silvain S Nicholls Ashley A Ros Xavier Romero XR Su Jing J Eldridge Matthew D MD Riedel Angela A Serrao Eva M EM Rodewald Hans-Reimer HR Mack Matthias M Shields Jacqueline D JD Cohen E Suzanne ES McKenzie Andrew N J ANJ Goodwin Richard J A RJA Brindle Kevin M KM Marioni John C JC Halim Timotheus Y F TYF
Nature immunology 20200803 9
Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a commonly affected organ. We found that activation of lung-resident group 2 innate lymphoid cells (ILC2s) orchestrated suppression of natural killer (NK) cell-mediated innate antitumor immunity, leading to increased lung metastases and mortality. Using multiple models of lung metastasis, we show that interleukin (IL)-33-dependent ILC2 activation in the lung is involved centrally in promoting tumor burden. ILC ...[more]