Orai channels: key players in Ca2+ homeostasis.
Ontology highlight
ABSTRACT:
SUBMITTER: Sallinger M
PROVIDER: S-EPMC7116546 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Orai channels: key players in Ca<sup>2+</sup> homeostasis.
Sallinger Matthias M Berlansky Sascha S Frischauf Irene I
Current opinion in physiology 20200629
Maintaining a precise calcium (Ca<sup>2+</sup>) balance is vital for cellular survival. The most prominent pathway to shuttle Ca<sup>2+</sup> into cells is the Ca<sup>2+</sup> release activated Ca<sup>2+</sup> (CRAC) channel. Orai proteins are indispensable players in this central mechanism of Ca<sup>2+</sup> entry. This short review traces the latest articles published in the field of CRAC channel signalling with a focus on the structure of the pore-forming Orai proteins, the propagation of the ...[more]
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