Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC7116597 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Chen Xu X Gustafsson Stefan S Whitington Thomas T Borné Yan Y Lorentzen Erik E Sun Jitong J Almgren Peter P Su Jun J Karlsson Robert R Song Jie J Lu Yi Y Zhan Yiqiang Y Hägg Sara S Svensson Per P Smedby Karin E KE Slager Susan L SL Ingelsson Erik E Lindgren Cecilia M CM Morris Andrew P AP Melander Olle O Karlsson Thomas T de Faire Ulf U Caidahl Kenneth K Engström Gunnar G Lind Lars L Karlsson Mikael C I MCI Pedersen Nancy L NL Frostegård Johan J Magnusson Patrik K E PKE
Human molecular genetics 20180501 10
Phosphorylcholine (PC) is an epitope on oxidized low-density lipoprotein (oxLDL), apoptotic cells and several pathogens like Streptococcus pneumoniae. Immunoglobulin M against PC (IgM anti-PC) has the ability to inhibit uptake of oxLDL by macrophages and increase clearance of apoptotic cells. From our genome-wide association studies (GWASs) in four European-ancestry cohorts, six single nucleotide polymorphisms (SNPs) in 11q24.1 were discovered (in 3002 individuals) and replicated (in 646 individ ...[more]