Ontology highlight
ABSTRACT:
SUBMITTER: Claussnitzer M
PROVIDER: S-EPMC7116609 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Claussnitzer Melina M Dankel Simon N SN Klocke Bernward B Grallert Harald H Glunk Viktoria V Berulava Tea T Lee Heekyoung H Oskolkov Nikolay N Fadista Joao J Fadista Joao J Ehlers Kerstin K Wahl Simone S Hoffmann Christoph C Qian Kun K Rönn Tina T Riess Helene H Müller-Nurasyid Martina M Bretschneider Nancy N Schroeder Timm T Skurk Thomas T Horsthemke Bernhard B Spieler Derek D Klingenspor Martin M Seifert Martin M Kern Michael J MJ Mejhert Niklas N Dahlman Ingrid I Hansson Ola O Hauck Stefanie M SM Blüher Matthias M Arner Peter P Groop Leif L Illig Thomas T Suhre Karsten K Hsu Yi-Hsiang YH Mellgren Gunnar G Hauner Hans H Laumen Helmut H
Cell 20140101 1-2
Genome-wide association studies have revealed numerous risk loci associated with diverse diseases. However, identification of disease-causing variants within association loci remains a major challenge. Divergence in gene expression due to cis-regulatory variants in noncoding regions is central to disease susceptibility. We show that integrative computational analysis of phylogenetic conservation with a complexity assessment of co-occurring transcription factor binding sites (TFBS) can identify c ...[more]