The genetic and epigenetic basis of type 2 diabetes and obesity.
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ABSTRACT:
SUBMITTER: Drong AW
PROVIDER: S-EPMC7116747 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
The genetic and epigenetic basis of type 2 diabetes and obesity.
Drong A W AW Lindgren C M CM McCarthy M I MI
Clinical pharmacology and therapeutics 20121010 6
Type 2 diabetes (T2D) and obesity are complex disorders that constitute major public health problems. The evidence for familial aggregation of both T2D and obesity is substantial. To date, more than 150 genetic loci are associated with the development of monogenic, syndromic, or multifactorial forms of T2D or obesity. However, the proportion of overall trait variance explained by these associated loci is modest (~5-10% for T2D, ~2% for body mass index (BMI)). Some of the familial aggregation not ...[more]
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