Ontology highlight
ABSTRACT:
SUBMITTER: Lopez S
PROVIDER: S-EPMC7116784 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
López Saioa S Lim Emilia L EL Horswell Stuart S Haase Kerstin K Huebner Ariana A Dietzen Michelle M Mourikis Thanos P TP Watkins Thomas B K TBK Rowan Andrew A Dewhurst Sally M SM Birkbak Nicolai J NJ Wilson Gareth A GA Van Loo Peter P Jamal-Hanjani Mariam M Swanton Charles C McGranahan Nicholas N
Nature genetics 20200305 3
Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and prognostic relevance, the evolutionary selection pressures for WGD in cancer have not been investigated. Here, we combine evolutionary simulations with an analysis of cancer sequencing data to explore WGD during cancer evolution. Simulations suggest that WGD can be selected to mitigate the irreversible, ratchet-like, accumulation of deleterious ...[more]