Ontology highlight
ABSTRACT:
SUBMITTER: Balint S
PROVIDER: S-EPMC7116847 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Bálint Š Š Müller S S Fischer R R Kessler B M BM Harkiolaki M M Valitutti S S Dustin M L ML
Science (New York, N.Y.) 20200507 6493
Cytotoxic T lymphocytes (CTLs) kill infected and cancerous cells. We detected transfer of cytotoxic multiprotein complexes, called supramolecular attack particles (SMAPs), from CTLs to target cells. SMAPs were rapidly released from CTLs and were autonomously cytotoxic. Mass spectrometry, immunochemical analysis, and CRISPR editing identified a carboxyl-terminal fragment of thrombospondin-1 as an unexpected SMAP component that contributed to target killing. Direct stochastic optical reconstructio ...[more]