Ontology highlight
ABSTRACT:
SUBMITTER: Arter WE
PROVIDER: S-EPMC7116857 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Arter William E WE Xu Catherine K CK Castellana-Cruz Marta M Herling Therese W TW Krainer Georg G Saar Kadi L KL Kumita Janet R JR Dobson Christopher M CM Knowles Tuomas P J TPJ
Nano letters 20201020 11
Oligomers comprised of misfolded proteins are implicated as neurotoxins in the pathogenesis of protein misfolding conditions such as Parkinson's and Alzheimer's diseases. Structural, biophysical, and biochemical characterization of these nanoscale protein assemblies is key to understanding their pathology and the design of therapeutic interventions, yet it is challenging due to their heterogeneous, transient nature and low relative abundance in complex mixtures. Here, we demonstrate separation o ...[more]