Unknown

Dataset Information

0

The Aging Metabolome-Biomarkers to Hub Metabolites.


ABSTRACT: Aging biology is intimately associated with dysregulated metabolism, which is one of the hallmarks of aging. Aging-related pathways such as mTOR and AMPK, which are major targets of anti-aging interventions including rapamcyin, metformin, and exercise, either directly regulate or intersect with metabolic pathways. In this review, numerous candidate bio-markers of aging that have emerged using metabolomics are outlined. Metabolomics studies also reveal that not all metabolites are created equally. A set of core "hub" metabolites are emerging as central mediators of aging. The hub metabolites reviewed here are nicotinamide adenine dinucleotide, reduced nicotinamide dinucleotide phosphate, α-ketoglutarate, and β-hydroxybutyrate. These "hub" metabolites have signaling and epigenetic roles along with their canonical roles as co-factors or intermediates of carbon metabolism. Together these hub metabolites suggest a central role of the TCA cycle in signaling and metabolic dysregulation associated with aging.

SUBMITTER: Sharma R 

PROVIDER: S-EPMC7117067 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC10115486 | biostudies-literature
| S-EPMC3111869 | biostudies-literature
| S-EPMC9283946 | biostudies-literature
| S-EPMC8519999 | biostudies-literature
| S-EPMC9825447 | biostudies-literature
| S-EPMC10172467 | biostudies-literature
| S-EPMC7710283 | biostudies-literature
| S-EPMC6358022 | biostudies-literature
| S-EPMC5473407 | biostudies-other
| S-EPMC5473633 | biostudies-literature