RNA interference inhibits hepatitis E virus mRNA accumulation and protein synthesis in vitro.
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ABSTRACT:
SUBMITTER: Huang F
PROVIDER: S-EPMC7117326 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
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RNA interference inhibits hepatitis E virus mRNA accumulation and protein synthesis in vitro.
Huang Fen F Zhou Junfang J Yang Zhibiao Z Cui Li L Zhang Wen W Yuan Congli C Yang Shixing S Zhu Jianguo J Hua Xiuguo X
Veterinary microbiology 20091106 3-4
Hepatitis E virus (HEV) is a zoonotic pathogen to which several species, including human beings, pigs and rodents, are reported to be susceptible. To date, vaccines developed against HEV still need to be improved and a structural gene (ORF2), which encodes a capsid protein with high sequence conservation found across HEV genotypes, is a potential candidate. To exploit the possibility of using RNA interference (RNAi) as a strategy against HEV infection, four small interference RNA (siRNA) duplex ...[more]
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