Ontology highlight
ABSTRACT:
SUBMITTER: Tarancon R
PROVIDER: S-EPMC7117655 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Tarancón Raquel R Domínguez-Andrés Jorge J Uranga Santiago S Ferreira Anaísa V AV Groh Laszlo A LA Domenech Mirian M González-Camacho Fernando F Riksen Niels P NP Aguilo Nacho N Yuste José J Martín Carlos C Netea Mihai G MG
PLoS pathogens 20200402 4
Among infectious diseases, tuberculosis is the leading cause of death worldwide, and represents a serious threat, especially in developing countries. The protective effects of Bacillus Calmette-Guerin (BCG), the current vaccine against tuberculosis, have been related not only to specific induction of T-cell immunity, but also with the long-term epigenetic and metabolic reprogramming of the cells from the innate immune system through a process termed trained immunity. Here we show that MTBVAC, a ...[more]