Dataset Information

Higher thresholds for the utilization of steatotic allografts in liver transplantation: Analysis from a U.S. national database.

ABSTRACT:

Background

Historically, liver allografts with >30% macrosteatosis (MaS) on donor biopsy have been associated with early allograft dysfunction and worse graft survival; however, successful outcomes have been reported in small cohorts. This study proposes an elevated MaS threshold for organ utilization without detriment to graft survival.

Methods

The UNOS Standard Transplant Analysis and Research database was evaluated for transplants between 2006-2015. Graft survival up to 1-year was evaluated by Kaplan-Meier (KM) survival analyses, and by univariate and multivariable logistic regression analyses, including donor and recipient characteristics. Odds ratios (OR) with 95% confidence intervals (CI) for risk of graft loss are reported.

Results

Thirty-day risk of graft loss was increased with MaS as low as 10-19% (OR [95% CI] 1.301 [1.055-1.605], p<0.0001) and peaked with MaS 50-59% (2.921 [1.672-5.103]). At 1-year, risk of graft loss remained elevated with MaS 40-49% (1.465 [1.002-2.142]) and MaS 50-59% (1.978 [1.281-3.056], p = 0.0224). Multivariable models were created for Lower and Higher MELD recipients and MaS cutoffs were established. In Lower MELD recipients, organs with ?50% MaS had increased risk of graft loss at 30 days (2.451 [1.541-3.897], p = 0.0008) and 1-year post-transplant (1.720 [1.224-2.418], p = 0.0125). Higher MELD recipients had increased risk of graft loss at 30 days with allografts showing MaS ?40% (4.204 [1.440-5.076], p = 0.0016). At 1-year the risk remained increased, but MaS was not significant predictor of graft loss.048 [1.131-3.710], p = 0.0616). In both MELD cohorts, organs with MaS levels below threshold had similar survival to those transplanted without a donor biopsy.

Conclusions

In conjunction with recipient selection, organs with MaS up to 50% may be safely used without detriment to outcomes.

SUBMITTER: Steggerda JA

PROVIDER: S-EPMC7117730 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Higher thresholds for the utilization of steatotic allografts in liver transplantation: Analysis from a U.S. national database.

Steggerda Justin A JA Bloom Matthew B MB Noureddin Mazen M Brennan Todd V TV Todo Tsuyoshi T Nissen Nicholas N NN Klein Andrew S AS Kim Irene K IK

PloS one 20200402 4

<h4>Background</h4>Historically, liver allografts with >30% macrosteatosis (MaS) on donor biopsy have been associated with early allograft dysfunction and worse graft survival; however, successful outcomes have been reported in small cohorts. This study proposes an elevated MaS threshold for organ utilization without detriment to graft survival.<h4>Methods</h4>The UNOS Standard Transplant Analysis and Research database was evaluated for transplants between 2006-2015. Graft survival up to 1-year ...[more]

PMID: 32240235

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Dataset Information

Higher thresholds for the utilization of steatotic allografts in liver transplantation: Analysis from a U.S. national database.

Background

Methods

Results

Conclusions

Publications

Higher thresholds for the utilization of steatotic allografts in liver transplantation: Analysis from a U.S. national database.

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