Ontology highlight
ABSTRACT:
SUBMITTER: Knudsen ES
PROVIDER: S-EPMC7118159 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Communications biology 20200402 1
The retinoblastoma tumor suppressor gene (RB1) plays a critical role in coordinating multiple pathways that impact cancer initiation, disease progression, and therapeutic responses. Here we probed molecular features associated with the RB-pathway across 31 tumor-types. While the RB-pathway has been purported to exhibit multiple mutually exclusive genetic events, only RB1 alteration is mutually exclusive with deregulation of CDK4/6 activity. An ER+ breast cancer model with targeted RB1 deletion w ...[more]