Intranasal epinephrine effects on epinephrine pharmacokinetics and heart rate in a nasal congestion canine model.

ABSTRACT:

Background

Histamine release and vasodilation during an allergic reaction can alter the pharmacokinetics of drugs administered via the intranasal (IN) route. The current study evaluated the effects of histamine-induced nasal congestion on epinephrine pharmacokinetics and heart rate changes after IN epinephrine.

Methods

Dogs received 5% histamine or saline IN followed by 4 mg epinephrine IN. Nasal restriction pressure, epinephrine concentration, and heart rate were assessed. Maximum concentration (C_max), area under plasma concentration-time curve from 1 to 90 min (AUC_1-90), and time to reach C_max (T_max) were measured. Clinical observations were documented.

Results

In the 12 dogs in this study, nasal congestion occurred at 5-1

SUBMITTER: Tuttle R 

PROVIDER: S-EPMC7119008 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature