Value of digital mammography in predicting lymphovascular invasion of breast cancer.

ABSTRACT: BACKGROUND:Lymphovascular invasion (LVI) has never been revealed by preoperative scans. It is necessary to use digital mammography in predicting LVI in patients with breast cancer preoperatively. METHODS:Overall 122 cases of invasive ductal carcinoma diagnosed between May 2017 and September 2018 were enrolled and assigned into the LVI positive group (n?=?42) and the LVI negative group (n?=?80). Independent t-test and ?2 test were performed. RESULTS:Difference in Ki-67 between the two groups was statistically significant (P?=?0.012). Differences in interstitial edema (P?=?0.013) and skin thickening (P?=?0.000) were statistically significant between the two groups. Multiple factor analysis showed that there were three independent risk factors for LVI: interstitial edema (odds ratio [OR]?=?12.610; 95% confidence interval [CI]: 1.061-149.922; P?=?0.045), blurring of subcutaneous fat (OR?=?0.081; 95% CI: 0.012-0.645; P?=?0.017) and skin thickening (OR?=?9.041; 95% CI: 2.553-32.022; P?=?0.001). CONCLUSIONS:Interstitial edema, blurring of subcutaneous fat, and skin thickening are independent risk factors for LVI. The specificity of LVI prediction is as high as 98.8% when the three are used together.

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7119272 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature