Unknown

Dataset Information

0

Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong.

ABSTRACT: Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.

SUBMITTER: Chim SS 

PROVIDER: S-EPMC7119348 | biostudies-literature | 2003 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong.

Chim S S C SS   Tsui S K W SK   Chan K C A KC   Au T C C TC   Hung E C W EC   Tong Y K YK   Chiu R W K RW   Ng E K O EK   Ng E K O EK   Chan P K S PK   Chu C M CM   Sung J J Y JJ   Tam J S JS   Fung K P KP   Waye M M Y MM   Lee C Y CY   Yuen K Y KY   Lo Y M D YM  

Lancet (London, England) 20031101 9398

Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the f  ...[more]

Similar Datasets

Unknown The impact of community psychological responses on outbreak control for severe acute respiratory syndrome in Hong Kong.
| S-EPMC1732323 | biostudies-literature
Genomics Severe acute respiratory syndrome coronavirus 2 strain:Hong Kong/VM20001061/2020
| PRJNA639827 | ENA
Unknown Severe acute respiratory syndrome (SARS) and coronavirus disease-2019 (COVID-19): From causes to preventions in Hong Kong.
| S-EPMC7195109 | biostudies-literature
Unknown Territorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China.
| S-EPMC7774584 | biostudies-literature
Unknown Probable Animal-to-Human Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant AY.127 Causing a Pet Shop-Related Coronavirus Disease 2019 (COVID-19) Outbreak in Hong Kong.
| S-EPMC8903450 | biostudies-literature
Unknown Molecular epidemiology of the coronavirus associated with severe acute respiratory syndrome: a review of data from the Chinese University of Hong Kong.
| S-EPMC1904414 | biostudies-literature
Unknown Genomic sequencing of the severe acute respiratory syndrome-coronavirus.
| S-EPMC7121524 | biostudies-literature
Unknown CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese.
| S-EPMC7115401 | biostudies-literature
Unknown Genomic Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2, Colombia.
| S-EPMC7706936 | biostudies-literature
Unknown Scarlet fever outbreak, Hong Kong, 2011.
| S-EPMC3471616 | biostudies-literature