Ontology highlight
ABSTRACT:
SUBMITTER: He A
PROVIDER: S-EPMC7119369 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Life science alliance 20200331 5
Osteosarcoma (OS) is a primary malignant bone neoplasm with high frequencies of tumor metastasis and recurrence. Although the Akt/PKB signaling pathway is known to play key roles in tumorigenesis, the roles of cyclin-dependent kinase-like 3 (CDKL3) in OS progression remain largely elusive. We have demonstrated the high expression levels of CDKL3 in OS human specimens and comprehensively investigated the role of CDKL3 in promoting OS progression both in vitro and in vivo. We found that CDKL3 regu ...[more]