Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi A
PROVIDER: S-EPMC7119370 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Takahashi Akinori A Suzuki Toru T Soeda Shou S Takaoka Shohei S Kobori Shungo S Yamaguchi Tomokazu T Mohamed Haytham Mohamed Aly HMA Yanagiya Akiko A Abe Takaya T Shigeta Mayo M Furuta Yasuhide Y Kuba Keiji K Yamamoto Tadashi T
Life science alliance 20200401 5
The biological significance of deadenylation in global gene expression is not fully understood. Here, we show that the CCR4-NOT deadenylase complex maintains expression of mRNAs, such as those encoding transcription factors, cell cycle regulators, DNA damage response-related proteins, and metabolic enzymes, at appropriate levels in the liver. Liver-specific disruption of <i>Cnot1</i>, encoding a scaffold subunit of the CCR4-NOT complex, leads to increased levels of mRNAs for transcription factor ...[more]