Detection and Comparative Analysis of Methylomic Biomarkers of Rheumatoid Arthritis.
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ABSTRACT:
SUBMITTER: Feng X
PROVIDER: S-EPMC7119472 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Detection and Comparative Analysis of Methylomic Biomarkers of Rheumatoid Arthritis.
Feng Xin X Hao Xubing X Shi Ruoyao R Xia Zhiqiang Z Huang Lan L Yu Qiong Q Zhou Fengfeng F
Frontiers in genetics 20200327
Rheumatoid arthritis (RA) is a common autoimmune disorder influenced by both genetic and environmental factors. To investigate possible contributions of DNA methylation to the etiology of RA with minimum confounding genetic heterogeneity, we investigated genome-wide DNA methylation in disease-discordant monozygotic twin pairs. This study hypothesized that methylomic biomarkers might facilitate accurate RA detection. A comprehensive series of biomarker detection algorithms were utilized to find t ...[more]
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