Non-lethal growth inhibition by arresting the starch utilization system of clinically relevant human isolates of Bacteroides dorei.
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ABSTRACT:
SUBMITTER: Santilli AD
PROVIDER: S-EPMC7120511 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Non-lethal growth inhibition by arresting the starch utilization system of clinically relevant human isolates of <i>Bacteroides dorei</i>.
Santilli Anthony D AD Russell Jordan T JT Triplett Eric W EW Whitehead Kristi J KJ Whitehead Daniel C DC
MedChemComm 20190705 11
We describe the inhibition of the starch utilization system (Sus) belonging to various strains of <i>Bacteroides dorei</i> in a non-lethal manner using the small molecule probe, acarbose. Concentrations of acarbose as low as 5 μM significantly impede the growth of <i>B. dorei</i> and increase the doubling time of cultures. The successful inhibition of this species of <i>Bacteroides</i> is relevant to several disease states including type I diabetes mellitus. This method continues to explore a ne ...[more]
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