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Emerging Pharmacological Treatments for Cerebral Edema: Evidence from Clinical Studies.

ABSTRACT: Cerebral edema, a common and often fatal companion to most forms of acute central nervous system disease, has been recognized since the time of ancient Egypt. Unfortunately, our therapeutic armamentarium remains limited, in part due to historic limitations in our understanding of cerebral edema pathophysiology. Recent advancements have led to a number of clinical trials for novel therapeutics that could fundamentally alter the treatment of cerebral edema. In this review, we discuss these agents, their targets, and the data supporting their use, with a focus on agents that have progressed to clinical trials.

SUBMITTER: Stokum JA

PROVIDER: S-EPMC7122796 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Emerging Pharmacological Treatments for Cerebral Edema: Evidence from Clinical Studies.

Stokum Jesse A JA Gerzanich Volodymyr V Sheth Kevin N KN Kimberly W Taylor WT Simard J Marc JM

Annual review of pharmacology and toxicology 20200101

Cerebral edema, a common and often fatal companion to most forms of acute central nervous system disease, has been recognized since the time of ancient Egypt. Unfortunately, our therapeutic armamentarium remains limited, in part due to historic limitations in our understanding of cerebral edema pathophysiology. Recent advancements have led to a number of clinical trials for novel therapeutics that could fundamentally alter the treatment of cerebral edema. In this review, we discuss these agents, ...[more]

PMID: 31914899

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