Dataset Information

Annual SO₂ exposure, asthma, atopy, and lung function in Puerto Rican children.

ABSTRACT:

Background

Long-term effects of sulfur dioxide (SO₂ ) exposure on children, a vulnerable population, are largely unknown. Further, how long-term SO₂ affects Puerto Rican children living in the island of Puerto Rico, a group with high asthma prevalence, is unclear. We evaluated the effects of annual average 1-hour daily maximum SO₂ average on asthma, atopy, total immunoglobulin E (IgE), and lung function in Puerto Rican children.

Methods

A cohort of 678 children (351 with asthma, 327 without asthma) was recruited in Puerto Rico from 2009 to 2010. Annual average 1-hour daily maximum SO₂ exposure was interpolated utilizing publicly available monitoring data. Multivariable logistic and linear regression was used for the analysis of asthma, atopy (defined as an IgE ?0.35 IU/mL to at least one of five common aero-allergens), total IgE, and lung function measures (forced vital capacity [FVC], forced expiratory volume in 1?second [FEV1], and FEV1/FVC ratio).

Results

Annual SO₂ exposure (per 1?ppb) was significantly associated with asthma (odds ratio [OR]?=?1.42; 95% confidence interval [CI]?=?1.05-1.91) and atopy (OR?=?1.35; 95% CI?=?1.02-1.78). Such exposure was also significantly associated with lower FEV1/FVC in all children (??=?-1.42; 95% CI?=?-2.78 to -0.08) and in children with asthma (??=?-2.39; 95% CI=?-4.31 to -0.46). Annual SO₂ exposure was not significantly associated with total IgE, FEV1, or FVC.

Conclusions

Among Puerto Rican children in Puerto Rico, long-term SO₂ exposure is linked to asthma and atopy. In these children, long-term SO₂ exposure is also associated with reduced FEV1/FVC, particularly in those with asthma.

SUBMITTER: Rosser F

PROVIDER: S-EPMC7122992 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Publications

Annual SO<sub>2</sub> exposure, asthma, atopy, and lung function in Puerto Rican children.

Rosser Franziska F Forno Erick E Kurland Kristen S KS Han Yueh-Ying YY Mair Christina C Acosta-Pérez Edna E Canino Glorisa G Celedón Juan C JC

Pediatric pulmonology 20191205 2

<h4>Background</h4>Long-term effects of sulfur dioxide (SO<sub>2</sub> ) exposure on children, a vulnerable population, are largely unknown. Further, how long-term SO<sub>2</sub> affects Puerto Rican children living in the island of Puerto Rico, a group with high asthma prevalence, is unclear. We evaluated the effects of annual average 1-hour daily maximum SO<sub>2</sub> average on asthma, atopy, total immunoglobulin E (IgE), and lung function in Puerto Rican children.<h4>Methods</h4>A cohort of ...[more]

PMID: 31805225

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Project description:Changes in dietary patterns may partly explain the epidemic of asthma in industrialized countries. The objective of this study was to examine the relationship between dietary patterns and lung function and asthma exacerbations in Puerto Rican children. This is a case-control study of 678 Puerto Rican children (ages 6-14 years) in San Juan (Puerto Rico). All participants completed a respiratory health questionnaire and a 75-item food frequency questionnaire. Food items were aggregated into 7 groups: fruits, vegetables, grains, protein, dairy, fats, and sweets. Logistic regression was used to evaluate consumption frequency of each group and asthma. Based on the results, a dietary score was created [range from -2 (unhealthy diet: high consumption of dairy and sweets, low consumption of vegetables and grains) to 2 (healthy diet: high consumption of vegetables and grains and low consumption of dairy and sweet)]. Multivariable linear or logistic regression was used to assess the relationship between dietary score and lung function or asthma exacerbations. After adjustment for covariates, a healthier diet (each 1-point increment in dietary score) was associated with significantly higher %predicted forced expiratory volume in the first second (FEV1) and %predicted forced vital capacity (FVC) in control subjects. Dietary pattern alone was not associated with asthma exacerbations, but children with an unhealthy diet and vitamin D insufficiency (plasma 25(OH)D <30?ng/mL) had higher odds of ?1 severe asthma exacerbation [odds ratio (OR)?=?3.4, 95% confidence interval (CI)?=?1.5-7.5] or ?1 hospitalization due to asthma (OR?=?3.9, 95% CI?=?1.6-9.8, OR?=?3.4, 95% CI?=?1.5-7.5) than children who ate a healthy diet and were vitamin D sufficient. A healthy diet, with frequent consumption of vegetables and grains and low consumption of dairy products and sweets, was associated with higher lung function (as measured by FEV1 and FVC). Vitamin D insufficiency, together with an unhealthy diet, may have detrimental effects on asthma exacerbations in children.

Dataset Information

Annual SO₂ exposure, asthma, atopy, and lung function in Puerto Rican children.

Background

Methods

Results

Conclusions

Publications

Annual SO<sub>2</sub> exposure, asthma, atopy, and lung function in Puerto Rican children.

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Annual SO2 exposure, asthma, atopy, and lung function in Puerto Rican children.

Background

Methods

Results

Conclusions

Publications

Annual SO<sub>2</sub> exposure, asthma, atopy, and lung function in Puerto Rican children.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Annual SO₂ exposure, asthma, atopy, and lung function in Puerto Rican children.