Ontology highlight
ABSTRACT:
SUBMITTER: Tani T
PROVIDER: S-EPMC7123644 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Tani Tohru T Shimizu Tomoharu T Tani Masaji M Shoji Hisataka H Endo Yoshihiro Y
Advances in experimental medicine and biology 20190101
Polymyxin B is an antibiotic that shows strong bactericidal activity against Gram-negative bacteria, by binding to and inactivating endotoxin. Systemic administration of polymyxin B in humans is restricted because of its nephrotoxicity and neurotoxicity, and this compound was therefore considered a strong candidate ligand for the extracorporeal selective adsorption of circulating endotoxin in the blood. Toraymyxin® is a direct hemoperfusion column that uses polymyxin B attached to an insoluble c ...[more]