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Potential targets for anti-SARS drugs in the structural proteins from SARS related coronavirus.

ABSTRACT: This is a further study on the severe acute respiratory syndrome (SARS) using the probabilistic models. The purpose was to define the potential targets for anti-SARS drugs in the structural proteins from human SARS related coronavirus (SARS-CoV) while knowing little about the functional sites and possible mutations in these proteins. From a probabilistic viewpoint, we can theoretically select the amino acid pairs as potential candidates for anti-SARS drugs. These candidates have a greater chance of colliding with anti-SARS drugs, are more likely to link with the protein functions and are less vulnerable to mutations.

SUBMITTER: Wu G

PROVIDER: S-EPMC7124239 | biostudies-literature | 2004 Jun

REPOSITORIES: biostudies-literature

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Potential targets for anti-SARS drugs in the structural proteins from SARS related coronavirus.

Wu Guang G Yan Shaomin S

Peptides 20040601 6

This is a further study on the severe acute respiratory syndrome (SARS) using the probabilistic models. The purpose was to define the potential targets for anti-SARS drugs in the structural proteins from human SARS related coronavirus (SARS-CoV) while knowing little about the functional sites and possible mutations in these proteins. From a probabilistic viewpoint, we can theoretically select the amino acid pairs as potential candidates for anti-SARS drugs. These candidates have a greater chance ...[more]

PMID: 15203235

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