Dataset Information

Diet and colorectal cancer in UK Biobank: a prospective study.

ABSTRACT:

Background

Most of the previous studies on diet and colorectal cancer were based on diets consumed during the 1990s.

Methods

We used Cox-regression models to estimate adjusted hazard ratios for colorectal cancer by dietary factors in the UK Biobank study. Men and women aged 40-69?years at recruitment (2006-10) reported their diet on a short food-frequency questionnaire (n?=?475 581). Dietary intakes were re-measured in a large sub-sample (n?=?175?402) who completed an online 24-hour dietary assessment during follow-up. Trends in risk across the baseline categories were calculated by assigning re-measured intakes to allow for measurement error and changes in intake over time.

Results

During an average of 5.7?years of follow-up, 2609 cases of colorectal cancer occurred. Participants who reported consuming an average of 76?g/day of red and processed meat compared with 21?g/day had a 20% [95% confidence interval (CI): 4-37] higher risk of colorectal cancer. Participants in the highest fifth of intake of fibre from bread and breakfast cereals had a 14% (95% CI: 2-24) lower risk of colorectal cancer. Alcohol was associated with an 8% (95% CI: 4-12) higher risk per 10?g/day higher intake. Fish, poultry, cheese, fruit, vegetables, tea and coffee were not associated with colorectal-cancer risk.

Conclusions

Consumption of red and processed meat at an average level of 76 g/d that meets the current UK government recommendation (?90?g/day) was associated with an increased risk of colorectal cancer. Alcohol was also associated with an increased risk of colorectal cancer, whereas fibre from bread and breakfast cereals was associated with a reduced risk.

SUBMITTER: Bradbury KE

PROVIDER: S-EPMC7124508 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Publications

Diet and colorectal cancer in UK Biobank: a prospective study.

Bradbury Kathryn E KE Murphy Neil N Key Timothy J TJ

International journal of epidemiology 20200201 1

<h4>Background</h4>Most of the previous studies on diet and colorectal cancer were based on diets consumed during the 1990s.<h4>Methods</h4>We used Cox-regression models to estimate adjusted hazard ratios for colorectal cancer by dietary factors in the UK Biobank study. Men and women aged 40-69 years at recruitment (2006-10) reported their diet on a short food-frequency questionnaire (n = 475 581). Dietary intakes were re-measured in a large sub-sample (n = 175 402) who completed an online 24-ho ...[more]

PMID: 30993317

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Dataset Information

Diet and colorectal cancer in UK Biobank: a prospective study.

Background

Methods

Results

Conclusions

Publications

Diet and colorectal cancer in UK Biobank: a prospective study.

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