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Genome elimination mediated by gene expression from a selfish chromosome.


ABSTRACT: Numerous plants and animals harbor selfish B chromosomes that "drive" or transmit themselves at super-Mendelian frequencies, despite long-term fitness costs to the organism. Currently, it is unknown how B chromosome drive is mediated, and whether B-gene expression plays a role. We used modern sequencing technologies to analyze the fine-scale sequence composition and expression of paternal sex ratio (PSR), a B chromosome in the jewel wasp Nasonia vitripennis. PSR causes female-to-male conversion by destroying the sperm's hereditary material in young embryos to drive. Using RNA interference, we demonstrate that testis-specific expression of a PSR-linked gene, named haploidizer, facilitates this genome elimination-and-sex conversion effect. haploidizer encodes a putative protein with a DNA binding domain, suggesting a functional link with the sperm-derived chromatin.

SUBMITTER: Dalla Benetta E 

PROVIDER: S-EPMC7124933 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Genome elimination mediated by gene expression from a selfish chromosome.

Dalla Benetta Elena E   Antoshechkin Igor I   Yang Ting T   Nguyen Hoa Quang My HQM   Ferree Patrick M PM   Akbari Omar S OS  

Science advances 20200403 14


Numerous plants and animals harbor selfish B chromosomes that "drive" or transmit themselves at super-Mendelian frequencies, despite long-term fitness costs to the organism. Currently, it is unknown how B chromosome drive is mediated, and whether B-gene expression plays a role. We used modern sequencing technologies to analyze the fine-scale sequence composition and expression of paternal sex ratio (PSR), a B chromosome in the jewel wasp <i>Nasonia vitripennis</i>. PSR causes female-to-male conv  ...[more]

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