Ontology highlight
ABSTRACT:
SUBMITTER: Corella AN
PROVIDER: S-EPMC7124974 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Corella Alexandra N AN Cabiliza Ordonio Ma Victoria Andrea MVA Coleman Ilsa I Lucas Jared M JM Kaipainen Arja A Nguyen Holly M HM Sondheim Daniel D Brown Lisha G LG True Lawrence D LD Lee John K JK MacPherson David D Nghiem Paul P Gulati Roman R Morrissey Colm C Corey Eva E Nelson Peter S PS
Clinical cancer research : an official journal of the American Association for Cancer Research 20191205 7
<h4>Purpose</h4>Small-cell neuroendocrine prostate cancer (SCNPC) exhibits an aggressive clinical course and incidence rates seem to be increasing following resistance to potent androgen receptor (AR) antagonists. Currently, treatment options are limited and few model systems are available to identify new approaches for treatment. We sought to evaluate commonalities between SCNPC and other aggressive neuroendocrine carcinomas to identify therapeutic targets.<h4>Experimental design</h4>We generat ...[more]