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Influenza virus and factors that are associated with ICU admission, pulmonary co-infections and ICU mortality.


ABSTRACT:

Purpose

While most influenza patients have a self-limited respiratory illness, 5-10% of hospitalized patients develop severe disease requiring ICU admission. The aim of this study was to identify influenza-specific factors associated with ICU admission and mortality. Furthermore, influenza-specific pulmonary bacterial, fungal and viral co-infections were investigated.

Methods

199 influenza patients, admitted to two academic hospitals in the Netherlands between 01-10-2015 and 01-04-2016 were investigated of which 45/199 were admitted to the ICU.

Results

A history of Obstructive/Central Sleep Apnea Syndrome, myocardial infarction, dyspnea, influenza type A, BMI?>?30, the development of renal failure and bacterial and fungal co-infections, were observed more frequently in patients who were admitted to the ICU, compared with patients at the normal ward. Co-infections were evident in 55.6% of ICU-admitted patients, compared with 20.1% of patients at the normal ward, mainly caused by Staphylococcus aureus, Streptococcus pneumoniae, and Aspergillus fumigatus. Non-survivors suffered from diabetes mellitus and (pre-existent) renal failure more often.

Conclusions

The current study indicates that a history of OSAS/CSAS, myocardial infarction and BMI?>?30 might be related to ICU admission in influenza patients. Second, ICU patients develop more pulmonary co-infections. Last, (pre-existent) renal failure and diabetes mellitus are more often observed in non-survivors.

SUBMITTER: Beumer MC 

PROVIDER: S-EPMC7125534 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

Influenza virus and factors that are associated with ICU admission, pulmonary co-infections and ICU mortality.

Beumer M C MC   Koch R M RM   van Beuningen D D   OudeLashof A M AM   van de Veerdonk F L FL   Kolwijck E E   van der Hoeven J G JG   Bergmans D C DC   Hoedemaekers C W E CWE  

Journal of critical care 20181115


<h4>Purpose</h4>While most influenza patients have a self-limited respiratory illness, 5-10% of hospitalized patients develop severe disease requiring ICU admission. The aim of this study was to identify influenza-specific factors associated with ICU admission and mortality. Furthermore, influenza-specific pulmonary bacterial, fungal and viral co-infections were investigated.<h4>Methods</h4>199 influenza patients, admitted to two academic hospitals in the Netherlands between 01-10-2015 and 01-04  ...[more]

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