Antiviral effect of amiloride on replication of foot and mouth disease virus in cell culture.

ABSTRACT: Recently, amiloride was shown to potently suppress Coxsackievirus B3 (CVB3) replication. In the current study, we investigated whether amiloride could also exhibit antiviral activity against foot-and-mouth disease virus (FMDV), which belongs to the same family (Picornaviridae) as CVB3. We found that amiloride exerted antiviral activity in a dose-dependent manner against two strains of FMDV in IBRS-2?cells, with slight cytotoxicity at 1000??M. Besides, amiloride did not inhibit the attachment and entry of FMDV in IBRS-2?cells, but prevented early viral replication. These data implied that amiloride could be a promising candidate for further research as a potential antiviral drug against FMDV infection.

SUBMITTER: Gong MJ 

PROVIDER: S-EPMC7125800 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature