Ontology highlight
ABSTRACT:
SUBMITTER: Gong MJ
PROVIDER: S-EPMC7125800 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Microbial pathogenesis 20190719
Recently, amiloride was shown to potently suppress Coxsackievirus B3 (CVB3) replication. In the current study, we investigated whether amiloride could also exhibit antiviral activity against foot-and-mouth disease virus (FMDV), which belongs to the same family (Picornaviridae) as CVB3. We found that amiloride exerted antiviral activity in a dose-dependent manner against two strains of FMDV in IBRS-2 cells, with slight cytotoxicity at 1000 μM. Besides, amiloride did not inhibit the attachment and ...[more]