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Antiviral effect of amiloride on replication of foot and mouth disease virus in cell culture.

ABSTRACT: Recently, amiloride was shown to potently suppress Coxsackievirus B3 (CVB3) replication. In the current study, we investigated whether amiloride could also exhibit antiviral activity against foot-and-mouth disease virus (FMDV), which belongs to the same family (Picornaviridae) as CVB3. We found that amiloride exerted antiviral activity in a dose-dependent manner against two strains of FMDV in IBRS-2?cells, with slight cytotoxicity at 1000??M. Besides, amiloride did not inhibit the attachment and entry of FMDV in IBRS-2?cells, but prevented early viral replication. These data implied that amiloride could be a promising candidate for further research as a potential antiviral drug against FMDV infection.

SUBMITTER: Gong MJ

PROVIDER: S-EPMC7125800 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Antiviral effect of amiloride on replication of foot and mouth disease virus in cell culture.

Gong Mei-Jiao MJ Chang Yan-Yan YY Shao Jun-Jun JJ Li Shi-Fang SF Zhang Yong-Guang YG Chang Hui-Yun HY

Microbial pathogenesis 20190719

Recently, amiloride was shown to potently suppress Coxsackievirus B3 (CVB3) replication. In the current study, we investigated whether amiloride could also exhibit antiviral activity against foot-and-mouth disease virus (FMDV), which belongs to the same family (Picornaviridae) as CVB3. We found that amiloride exerted antiviral activity in a dose-dependent manner against two strains of FMDV in IBRS-2 cells, with slight cytotoxicity at 1000 μM. Besides, amiloride did not inhibit the attachment and ...[more]

PMID: 31326561

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