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MRNA cap-1 methyltransferase in the SARS genome.


ABSTRACT: The 3D jury system has predicted the methyltransferase fold for the nsp13 protein of the SARS coronavirus. Based on the conservation of a characteristic tetrad of residues, the mRNA cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral therapy.

SUBMITTER: von Grotthuss M 

PROVIDER: S-EPMC7126025 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature

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mRNA cap-1 methyltransferase in the SARS genome.

von Grotthuss Marcin M   Wyrwicz Lucjan S LS   Rychlewski Leszek L  

Cell 20030601 6


The 3D jury system has predicted the methyltransferase fold for the nsp13 protein of the SARS coronavirus. Based on the conservation of a characteristic tetrad of residues, the mRNA cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral therapy. ...[more]

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