Dataset Information

Autoantibodies against appetite-regulating peptide hormones and neuropeptides: putative modulation by gut microflora.

ABSTRACT:

Objective

Peptide hormones synthesized in gastrointestinal and adipose tissues in addition to neuropeptides regulate appetite and body weight. Previously, autoantibodies directed against melanocortin peptides were found in patients with eating disorders; however, it remains unknown whether autoantibodies directed against other appetite-regulating peptides are present in human sera and whether their levels are influenced by gut-related antigens.

Methods

Healthy women were studied for the presence of immunoglobulin (Ig) G and IgA autoantibodies directed against 14 key appetite-regulating peptides. The concept of molecular mimicry was applied to search in silico whether bacteria, viruses, or fungi contain proteins with amino acid sequences identical to appetite-regulating peptides. In addition, autoantibodies serum levels were studied in germ-free and specific pathogen-free rats.

Results

We found these IgG and IgA autoantibodies directed against leptin, ghrelin, peptide YY, neuropeptide Y, and other appetite-regulating peptides are present in human sera at levels of 100-900 ng/mL. Numerous cases of sequence homology with these peptides were identified among commensal and pathogenic micro-organisms including Lactobacilli, bacteroides, Helicobacter pylori, Escherichia coli, and Candida species. Decreased levels of IgA autoantibodies directed against several appetite-regulating peptides and increased levels of antighrelin IgG were found in germ-free rats compared with specific pathogen-free rats.

Conclusion

Healthy humans and rats display autoantibodies directed against appetite-regulating peptide hormones and neuropeptides, suggesting that these autoantibodies may have physiologic implications in hunger and satiety pathways. Gut-related antigens including the intestinal microflora may influence production of theses autoantibodies, suggesting a new link between the gut and appetite control.

SUBMITTER: Fetissov SO

PROVIDER: S-EPMC7126273 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature

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Publications

Autoantibodies against appetite-regulating peptide hormones and neuropeptides: putative modulation by gut microflora.

Fetissov Sergueï O SO Hamze Sinno Maria M Coëffier Moïse M Bole-Feysot Christine C Ducrotté Philippe P Hökfelt Tomas T Déchelotte Pierre P

Nutrition (Burbank, Los Angeles County, Calif.) 20080208 4

<h4>Objective</h4>Peptide hormones synthesized in gastrointestinal and adipose tissues in addition to neuropeptides regulate appetite and body weight. Previously, autoantibodies directed against melanocortin peptides were found in patients with eating disorders; however, it remains unknown whether autoantibodies directed against other appetite-regulating peptides are present in human sera and whether their levels are influenced by gut-related antigens.<h4>Methods</h4>Healthy women were studied f ...[more]

PMID: 18262391

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Dataset Information

Autoantibodies against appetite-regulating peptide hormones and neuropeptides: putative modulation by gut microflora.

Objective

Methods

Results

Conclusion

Publications

Autoantibodies against appetite-regulating peptide hormones and neuropeptides: putative modulation by gut microflora.

Similar Datasets

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