Ontology highlight
ABSTRACT:
SUBMITTER: Sokolova AS
PROVIDER: S-EPMC7126328 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20130812 21
The synthesis and biological evaluation of a novel series of dimeric camphor derivatives are described. The resulting compounds were studied for their antiviral activity, cyto- and genotoxicity. Compounds 3a and 3d in which the quaternary nitrogen atoms are separated by the C5H10 and С9H18 aliphatic chain, exhibited the highest efficiency as an agent inhibiting the reproduction of the influenza virus A(H1N1)pdm09. The cytotoxicity data of compounds 3 and 4 revealed their moderate activity agains ...[more]