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Synthesis and evaluation of phenylisoserine derivatives for the SARS-CoV 3CL protease inhibitor.

ABSTRACT: Synthesis and evaluation of new scaffold phenylisoserine derivatives connected with the essential functional groups against SARS CoV 3CL protease are described. The phenylisoserine backbone was found by simulation on GOLD software and the structure activity relationship study of phenylisoserine derivatives gave SK80 with an IC50 value of 43?M against SARS CoV 3CL R188I mutant protease.

SUBMITTER: Konno H 

PROVIDER: S-EPMC7127027 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Synthesis and evaluation of phenylisoserine derivatives for the SARS-CoV 3CL protease inhibitor.

Konno Hiroyuki H   Onuma Takumi T   Nitanai Ikumi I   Wakabayashi Masaki M   Yano Shigekazu S   Teruya Kenta K   Akaji Kenichi K  

Bioorganic & medicinal chemistry letters 20170420 12

Synthesis and evaluation of new scaffold phenylisoserine derivatives connected with the essential functional groups against SARS CoV 3CL protease are described. The phenylisoserine backbone was found by simulation on GOLD software and the structure activity relationship study of phenylisoserine derivatives gave SK80 with an IC<sub>50</sub> value of 43μM against SARS CoV 3CL R188I mutant protease. ...[more]

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