Transition metal-free cross-coupling of furan ring with haloacetylenes.

ABSTRACT: On the example of menthofuran, a naturally abundant compound, it has been shown for the first time that the furan ring can be readily cross-coupled with acylhaloacetylenes in the solid Al2O3 powder at room temperature to afford the corresponding 2-ethynyl derivatives in up to 88% yield. The reaction represents a ring closing/ring opening process that includes reversible formation of the intermediate cycloadducts further producing acetylene derivatives with elimination of HHal.

SUBMITTER: Sobenina LN 

PROVIDER: S-EPMC7127138 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature