Ontology highlight
ABSTRACT:
SUBMITTER: Zeng R
PROVIDER: S-EPMC7127270 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Journal of molecular biology 20040701 1
Proteomics was used to identify a protein encoded by ORF 3a in a SARS-associated coronavirus (SARS-CoV). Immuno-blotting revealed that interchain disulfide bonds might be formed between this protein and the spike protein. ELISA indicated that sera from SARS patients have significant positive reactions with synthesized peptides derived from the 3a protein. These results are concordant with that of a spike protein-derived peptide. A tendency exists for co-mutation between the 3a protein and the sp ...[more]