Ontology highlight
ABSTRACT:
SUBMITTER: Kumarasamy D
PROVIDER: S-EPMC7127791 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Kumarasamy Dhanabal D Roy Biswajit Gopal BG Rocha-Pereira Joana J Neyts Johan J Nanjappan Satheeshkumar S Maity Subhasis S Mookerjee Musfiqua M Naesens Lieve L
Bioorganic & medicinal chemistry letters 20161205 2
A series of 4-substituted 3,4-dihydropyrimidine-2-ones (DHPM) was synthesized, characterized by IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and HRMS spectra. The compounds were evaluated in vitro for their antiviral activity against a broad range of DNA and RNA viruses, along with assessment for potential cytotoxicity in diverse mammalian cell lines. Compound 4m, which possesses a long lipophilic side chain, was found to be a potent and selective inhibitor of Punta Toro virus, a member of the Buny ...[more]