Ontology highlight
ABSTRACT:
SUBMITTER: Zhang K
PROVIDER: S-EPMC7127970 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Zhang Kai K Pomyen Yotsawat Y Barry Anna E AE Martin Sean P SP Khatib Subreen S Knight Lucy L Forgues Marshonna M Dominguez Dana A DA Parhar Ravinder R Shah Ashesh P AP Bodzin Adam S AS Wang Xin Wei XW Dang Hien H
Molecular cancer research : MCR 20200115 4
Deregulated RNA-binding proteins (RBP), such as Argonaute 2 (AGO2), mediate tumor-promoting transcriptomic changes during carcinogenesis, including hepatocellular carcinoma (HCC). While AGO2 is well characterized as a member of the RNA-induced silencing complex (RISC), which represses gene expression through miRNAs, its role as a bona fide RBP remains unclear. In this study, we investigated AGO2's role as an RBP that regulates the <i>MYC</i> transcript to promote HCC. Using mRNA and miRNA arrays ...[more]