Ontology highlight
ABSTRACT:
SUBMITTER: Lauenstein JU
PROVIDER: S-EPMC7128310 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Lauenstein Johannes U JU Scherm Michael J MJ Udgata Atul A Moncrieffe Martin C MC Fisher David I DI Gay Nicholas J NJ
Journal of immunology (Baltimore, Md. : 1950) 20200320 8
The B cell adaptor protein (BCAP) is a multimodular regulator of inflammatory signaling in diverse immune system cells. BCAP couples TLR signaling to phosphoinositide metabolism and inhibits MyD88-directed signal transduction. BCAP is recruited to the TLR signalosome forming multitypic interactions with the MAL and MyD88 signaling adaptors. In this study, we show that indirect dimerization of BCAP TIR is required for negative regulation of TLR signaling. This regulation is mediated by a transcri ...[more]