Ontology highlight
ABSTRACT:
SUBMITTER: Earle KE
PROVIDER: S-EPMC7128890 | biostudies-literature | 2005 Apr
REPOSITORIES: biostudies-literature
Earle K E KE Tang Q Q Zhou X X Liu W W Zhu S S Bonyhadi M L ML Bluestone J A JA
Clinical immunology (Orlando, Fla.) 20050401 1
Regulatory T cells (Tregs) have been shown to be critical in the balance between autoimmunity and tolerance and have been implicated in several human autoimmune diseases. However, the small number of Tregs in peripheral blood limits their therapeutic potential. Therefore, we developed a protocol that would allow for the expansion of Tregs while retaining their suppressive activity. We isolated CD4+CD25 hi cells from human peripheral blood and expanded them in vitro in the presence of anti-CD3 an ...[more]