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ABSTRACT:
Methods:This prospective cohort study was conducted during the 2018 winter influenza season. Adult patients with fever/respiratory symptoms (fever/RS group) were age- and sex-matched with patients without fever/RS (non-fever/RS group) in a 1:1 ratio. Respiratory viruses were tested using NxTAG™ Respiratory Pathogen Panel IVD, a commercially-available multiplex PCR panel.
Results:A total of 214 acutely hospitalized patients were included in the final analysis, consisting of 107 with fever/RS (fever/RS group), and 107 age- and sex-matched patients without fever/RS (non-fever/RS group). Respiratory viruses were detected in 34.1% (73/214) of patients, and co-infection occurred in 7.9% (17/214) of patients. The incidence of respiratory virus was higher in the fever/RS group than in the non-fever/RS group (44.9% (48/107) versus 23.4% (25/107), p 0.001). Influenza B virus, enterovirus/rhinovirus and coronaviruses were detected more frequently in the fever/RS group, whereas parainfluenza virus 4B and adenovirus were detected more frequently in the non-fever/RS group. Among the non-fever/RS group, chest discomfort was more common among patients tested positive for respiratory viruses than those without respiratory virus detected (44% (11/25) versus 22% (18/82), p 0.04).
Conclusions:Respiratory viruses can be frequently detected among hospitalized patients without typical features of respiratory tract infection. These patients may be a source of nosocomial outbreaks.
SUBMITTER: To KKW
PROVIDER: S-EPMC7129190 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
To K K W KKW Chan K-H KH Ho J J Pang P K P PKP Ho D T Y DTY Chang A C H ACH Seng C W CW Yip C C Y CCY Cheng V C C VCC Hung I F N IFN Yuen K-Y KY
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20190418 12
<h4>Objectives</h4>To determine the viral epidemiology and clinical characteristics of patients with and without clinically apparent respiratory tract infection.<h4>Methods</h4>This prospective cohort study was conducted during the 2018 winter influenza season. Adult patients with fever/respiratory symptoms (fever/RS group) were age- and sex-matched with patients without fever/RS (non-fever/RS group) in a 1:1 ratio. Respiratory viruses were tested using NxTAG™ Respiratory Pathogen Panel IVD, a c ...[more]