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Feline leishmaniosis: Is the cat a small dog?

ABSTRACT: Leishmania infantum is a vector-borne zoonotic disease transmitted by phlebotomine sand flies and dogs are considered the main reservoir of the parasite. Feline leishmaniosis (FeL) caused by L. infantum is an emergent feline disease more and more frequently reported in endemic areas. This review summarizes current knowledge focusing similarities and differences with canine leishmaniosis (CanL). Cats are infected by the same Leishmania species than dogs but prevalence of the infection is lower and cases of disease are less frequently reported. Scarce information is available on adaptive immune response of cats naturally exposed to L. infantum infection and mechanisms responsible for susceptibility or resistance of feline hosts. However, about half of clinical cases of FeL are reported in cats with possible impaired immunocompetence. Coinfections or comorbidities are frequently detected in sick cats and they can contribute to a misrepresentation of clinical FeL albeit lesions associated with the presence of the parasite have been detected in skin, lymph nodes, spleen, bone marrow, liver, oral mucosa, stomach, large bowel, kidney, nasal exudate, lung, eye. As for dogs, skin or mucocutaneous lesions are the most common reason for veterinary consultation and finding on physical examination in cats with leishmaniosis. Molecular investigations of Leishmania DNA and anti- Leishmania antibody detection are largely used with the same methodologies for both CanL and FeL, however few information is available about their diagnostic performance in feline hosts. Treatment of cats with clinical FeL is still empirically based and off label by using the most common drugs prescribed to dogs. Life expectancy of cats with clinical FeL is usually good unless concurrent conditions or complications occur and prognosis does not seem significantly influenced by therapy or retroviral coinfection. According to current knowledge, cats can play a role as additional reservoir host of L. infantum and, in a « One Health » perspective, preventative measures should be taken. In conclusion, albeit feline infection and the associated cat disease caused by L. infantum is increasingly reported in endemic areas and have many similarities with CanL, consolidated evidence-based knowledge is not available and we cannot exclude that important differences between dogs and cats exist about transmission, immunopathogenesis and best practice for management and prevention.

SUBMITTER: Pennisi MG

PROVIDER: S-EPMC7130840 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Feline leishmaniosis: Is the cat a small dog?

Pennisi Maria Grazia MG Persichetti Maria Flaminia MF

Veterinary parasitology 20180202

Leishmania infantum is a vector-borne zoonotic disease transmitted by phlebotomine sand flies and dogs are considered the main reservoir of the parasite. Feline leishmaniosis (FeL) caused by L. infantum is an emergent feline disease more and more frequently reported in endemic areas. This review summarizes current knowledge focusing similarities and differences with canine leishmaniosis (CanL). Cats are infected by the same Leishmania species than dogs but prevalence of the infection is lower an ...[more]

PMID: 29426470

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Project description:BACKGROUND:Renal disease is considered the main cause of natural mortality in dogs with canine leishmaniosis. The pathological mechanisms associated with kidney injury in canine leishmaniosis include immune complex glomerulonephritis, tubulointerstitial nephritis and occasionally renal amyloidosis. Proteinuria is a frequent finding in canine leishmaniosis and its quantification by the urine protein-creatinine ratio (UPC) is an important parameter in the staging of canine lesihmaniosis as presented by the LeishVet group. RESULTS:A 4.5 year-old spayed female Belgian Malinois dog was presented to the Hebrew University Veterinary Teaching hospital with epistaxis and rhinitis and diagnosed also with proteinuria and acute kidney injury (AKI IRIS grade V) associated with canine leishmaniosis that developed to LeishVet stage III with chronic kidney disease (CKD) after stabilization. Clinicopathologic abnormalities included azotemia with a peak creatinine concentration of 7.76 mg/dl (reference interval, 0.3-1.2 ng/dl), hypoalbuminemia (1.76 g/dl, reference interval 3-4.4 g/dl), hyperglobulinemia (4.54 g/dl, reference interval 1.8-3.9 g/dl) and proteinuria (urine protein/creatinine ratio 15.6, normal < 0.2). Serology by the enzyme-linked immunosorbent assay (ELISA) for Leishmania infantum was positive with high antibody levels. The dog was hospitalized and treated with intermittent hemodialysis, feeding through an esophageal feeding tube, medical treatment for protein losing nephropathy and antileishmanial treatment with allopurinol. Kidney function gradually improved and the dog's creatinine levels and proteinuria decreased until complete normalization two years after the acute insult. However, rhinitis and sneezing persisted and although the anti-leishmanial antibodies decreased over time, the dog remains constantly seropositive. CONCLUSIONS:To our knowledge, this is the first report of hemodialysis management of AKI associated with canine leishmaniosis. Hemodialysis was imperative in stabilizing the dog's renal disease and controlling its azotemia. It demostrates that hemodialysis can be beneficial in the management of acute deterioration of kidney disease in canine leishmaniosis.

Project description:Feline obesity is a highly prevalent disease that poses an urgent and serious challenge. Attempted treatment by weight reduction is often unsuccessful; a new preventative approach that focuses on the role of the owner may be helpful. This study used data collected from an international survey of cat owners designed to assess owner personality and self-control, owner-pet attachment, feeding practices, and the cat's body condition. Owner-reported body condition scores (BCS) of cats were assessed using images adapted from a 5-point BCS system and categorized as a binary dependent variable: overweight/obese (BCS 4-5) and not overweight (BCS 1-3). Owner-reported BCS scores using a verbal BCS scale were also used as a binary dependent variable. Of the 6,835 respondents, 30.5% described their cat as overweight/obese using the visual BCS scale, and 32.5% using the verbal scale. Multivariable logistic regression models were built using stepwise-backward selection. A total of 8 variables were significant using the visual score as the dependent variable, while 11 variables were significant using the verbal score as the dependent variable (p < 0.05). Low owner conscientiousness was associated with an increased risk of feline overweight/obesity (OR = 1.23, 95% CI 1.10-1.38), whereas preference for delayed reward was associated with a decreased risk (OR = 0.84, 95% CI 0.75-0.96). Contrary to expectation, indulgent (OR = 0.76, 95% CI 0.53-0.91) and inconsistent (OR = 0.86, 95% CI 0.76-0.93) feeding practices appeared protective. Other significant variables (p < 0.05) included cat-related factors (age, gender, housing, source) and management-related factors (dry diet, supermarket dry diet, raw diet, stealing, hunting, and measuring food with a scoop). A third multivariable analysis was performed, using results from cats classified as overweight/obese using both scoring methods, compared with cats classified as a healthy weight using both scoring methods. A total of 10 variables were found to be significant (p < 0.05). There was significant overlap of results from all three analyses. The results of this study indicate that feline obesity is a complex problem, with many contributing risk factors. It is essential to recognize the importance of owner characteristics, and that the prevention of obesity in cats may require the development of a range of interventional strategies.

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Feline leishmaniosis: Is the cat a small dog?

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Feline leishmaniosis: Is the cat a small dog?

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