Dataset Information

RP11-81H3.2 promotes gastric cancer progression through miR-339-HNRNPA1 interaction network.

ABSTRACT: Recent studies have demonstrated that various long non-coding RNAs (lncRNAs) participate in the gastric cancer (GC) development and metastasis. Some lncRNAs exert their regulatory function by interacting with microRNAs. Here we identified a novel lncRNA RP11-81H3.2 that was highly expressed in the GC tissue and cell lines. RP11-81H3.2 knockdown significantly inhibited the proliferation, migration, and invasion of GC cells. Mechanistically, we demonstrated that RP11-81H3.2 directly interacted with miR-339 while miR-339 regulated the HNRNPA1 expression by targeting HRRNPA1 3'-UTR. RP11-81H3.2-miR-339-HNRNPA1 interaction network regulated the GC cell proliferation, migration, and invasion. Moreover, our results confirmed that RP11-81H3.2 knockdown suppressed the tumor growth of GC in a xenograft model in vivo. In summary, the results suggest that RP11-81H3.2 functions as an oncogene in GC and could be utilized as a promising diagnosis and therapeutic marker for GC treatment.

SUBMITTER: Chen FR

PROVIDER: S-EPMC7131847 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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RP11-81H3.2 promotes gastric cancer progression through miR-339-HNRNPA1 interaction network.

Chen Fen-Rong FR Sha Su-Mei SM Wang Shen-Hao SH Shi Hai-Tao HT Dong Lei L Liu Dong D Cheng Yan Y An Miao M Wang Yan Y Zhang Jun J

Cancer medicine 20200213 7

Recent studies have demonstrated that various long non-coding RNAs (lncRNAs) participate in the gastric cancer (GC) development and metastasis. Some lncRNAs exert their regulatory function by interacting with microRNAs. Here we identified a novel lncRNA RP11-81H3.2 that was highly expressed in the GC tissue and cell lines. RP11-81H3.2 knockdown significantly inhibited the proliferation, migration, and invasion of GC cells. Mechanistically, we demonstrated that RP11-81H3.2 directly interacted wit ...[more]

PMID: 32052594

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Dataset Information

RP11-81H3.2 promotes gastric cancer progression through miR-339-HNRNPA1 interaction network.

Publications

RP11-81H3.2 promotes gastric cancer progression through miR-339-HNRNPA1 interaction network.

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