Repurposing Pirfenidone for Nonalcoholic Steatohepatitis-related Cirrhosis: A Case Series.
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ABSTRACT:
SUBMITTER: Philips CA
PROVIDER: S-EPMC7132022 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Repurposing Pirfenidone for Nonalcoholic Steatohepatitis-related Cirrhosis: A Case Series.
Philips Cyriac Abby CA Padsalgi Guruprasad G Ahamed Rizwan R Paramaguru Rajaguru R Rajesh Sasidharan S George Tom T Mahadevan Pushpa P Augustine Philip P
Journal of clinical and translational hepatology 20200224 1
We repurposed the antifibrotic drug pirfenidone-which is approved for treatment of idiopathic lung fibrosis-in a series of patients with nonalcoholic steatohepatitis-related cirrhosis. Our report demonstrates the observed improvements in necroinflammation and regression of cirrhosis with pirfenidone use for 12-weeks, associated with classical hepatic repair complex features on follow-up liver biopsies. This novel work could help stimulate further randomized trials of pirfenidone in patients with ...[more]
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