Ontology highlight
ABSTRACT:
SUBMITTER: Jenkins EC
PROVIDER: S-EPMC7132179 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
EMBO reports 20200223 4
Defects in the proteasome can result in pathological proteinopathies. However, the pathogenic role of sex- and tissue-specific sensitivity to proteotoxic stress remains elusive. Here, we map the proteasome activity across nine tissues, in male and female mice, and demonstrate strong sexual dimorphism in proteasome activity, where females have significantly higher activity in several tissues. Further, we report drastic differences in proteasome activity among tissues, independently of proteasome ...[more]