Ontology highlight
ABSTRACT:
SUBMITTER: Leboeuf D
PROVIDER: S-EPMC7132617 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Leboeuf Dominique D Abakumova Tatiana T Prikazchikova Tatiana T Rhym Luke L Anderson Daniel G DG Zatsepin Timofei S TS Piatkov Konstantin I KI
Molecular therapy : the journal of the American Society of Gene Therapy 20200121 4
The N-degron pathway is an emerging target for anti-tumor therapies, because of its capacity to positively regulate many hallmarks of cancer, including angiogenesis, cell proliferation, motility, and survival. Thus, inhibition of the N-degron pathway offers the potential to be a highly effective anti-cancer treatment. With the use of a small interfering RNA (siRNA)-mediated approach for selective downregulation of the four Arg/N-degron-dependent ubiquitin ligases, UBR1, UBR2, UBR4, and UBR5, we ...[more]